アブストラクト(51巻2号:神奈川歯学)

神奈川歯学

Japanese

Title : ラット顎下神経節におけるVIP陽性及びNPY陽性ニューロンの局在について
Subtitle : 原著
Authors : 小口岳史, 東一善*, 河田亮*, 飯村彰**, 松尾雅斗**, 尾之上さくら***, 高橋理*
Authors(kana) :
Organization : 神奈川歯科大学総合教育部, *神奈川歯科大学大学院口腔科学講座神経発生組織学分野, **神奈川歯科大学大学院口腔科学講座歯科形態学分野, ***関東学院大学理工学部
Journal : 神奈川歯学
Volume : 51
Number : 2
Page : 82-90
Year/Month : 2016 / 12
Article : 原著
Publisher : 神奈川歯科大学学会
Abstract : 「序論」延髄の上唾液核ニューロンより顎下神経節へは自律神経系の節前神経線維による直接投射が知られ, 顎下腺および舌下腺の分泌などに関与する. この顎下神経節はヒトの顎下三角に位置するが, ラットでは顎下腺主導管の長軸に沿う結合組織において, 顎下腺の門より咬筋後縁まで柱状の形態を呈する. このラット顎下神経節の節後神経線維は顎下腺, 舌下腺の腺体ならびに主導管に分布し, 主導管における分泌機能と吸収機能に影響を与える. 従来, 顎下腺主導管は唾液を口腔に輸送する管系であると考えられてきたため, その機能に関する報告は少数であった. しかし, 腺体から分泌された唾液の成分を顎下腺主導管が調節することが報告され, またその上皮細胞の中に化学受容を行う刷子細胞が存在することも報告されている. さらに免疫組織化学的研究によると, 顎下腺主導管にみられる刷子細胞は血管作働性腸管ペプチドvasoactive intestinal polypeptide(VIP)免疫陽性を示す.
Practice : 歯科学
Keywords : 顎下神経節, VIP, NPY, 免疫組織化学

English

Title : Localization of VIP and NPY immunoreactive neurons in the rat submandibular ganglion
Subtitle :
Authors : Takeshi OGUCHI, Kazuyoshi HIGASHI*, Akira KAWATA*, Akira IIMURA**, Masato MATSUO**, Sakura ONOUE***, Osamu TAKAHASHI*
Authors(kana) :
Organization : Division of Curriculum Development, Kanagawa Dental University, *Department of Histology, Embryology and Neuroanatomy, Kanagawa Dental University, School of Dentistry, **Department of Oral Science, Kanagawa Dental University, School of Dentistry, ***College of Science and Engineering, Kanto Gakuin University
Journal : Kanagawa Shigaku
Volume : 51
Number : 2
Page : 82-90
Year/Month : 2016 / 12
Article : Original article
Publisher : Kanagawa Odontological Society
Abstract : [Abstract] The submandibular ganglion (SMG) has been considered to be involved in the parasympathetic nervous system. Many studies of SMG have shown that SMG is not only a relay center, but may have more complicated functions. The present study was designed to examine the distribution of vasoactive intestinal polypeptide (VIP)-and neuropeptide Y (NPY)-immunoreactive neurons in SMG with a confocal laser microscope and to investigate the ultrastructure of SMG with an electron microscope. Moreover, three-dimensional configurations of the main excretory duct, capillary vessel network, and SMG in rats were reconstructed by the serial section method using an optical microscope. Clusters of neuronal cell bodies of SMG were observed along the main excretory duct. The nerve fibers extended from SMG around the hilum. A capillary network was observed in connective tissue around the main excretory duct. Although most of the SMG neurons showed NPY immunoreactivity, no neuron around the hilum showed NPY immunoreactivity. The ganglion neurons around the hilum showed VIP immunoreactivity, while NPY immunoreactive neurons were not observed in this portion of SMG. Electron microscope observation revealed no morphological difference among the neuronal cell bodies around the hilum or in any other part. VIP-immunoreactive fibers were observed near capillary vessels around the main excretory duct, suggesting that the mechanism underlying effects on saliva in the main excretory duct may be regulated by VIP-immunoreactive neurons through the capillary vessels. Most of the SMG neuronal cell bodies showed NPY immunoreactivity, and VIP-immunoreactive neurons were localized to SMG around the hilum.
Practice : Dentistry
Keywords : VIP, NPY