アブストラクト(49巻1号:神奈川歯学)

神奈川歯学

Japanese

Title : シェーグレン症候群患者における口唇腺生検所見と唾液腺機能の関連についての研究
Subtitle : 原著
Authors : 島田健雄, 久保田英朗, 石田孝文, 小澤重幸, 鈴木健司, 土肥雅彦, 岩渕博史, 本間義郎, 窪田展久*
Authors(kana) :
Organization : 神奈川歯科大学大学院顎顔面外科学講座, *神奈川歯科大学附属病院病理診断科
Journal : 神奈川歯学
Volume : 49
Number : 1
Page : 34-40
Year/Month : 2014 / 6
Article : 原著
Publisher : 神奈川歯科大学学会
Abstract : 「緒言」シェーグレン症候群(SS)は涙腺, 唾液腺におけるリンパ球浸潤により外分泌腺が破壊され, 眼乾燥, 口腔乾燥を主徴とする臓器特異的自己免疫疾患であるが, 同時に多種類の自己抗体産生と全身性の臓器障害を伴い, リンパ増殖疾患を発症するユニークな全身性の自己免疫疾患でもある. 本邦ではSSの診断について, 1999年の日本厚生省シェーグレン症候群改訂診断基準が用いられ, 4つの診断項目のうち2つ以上を満たせば, SSと診断することになっている. その中で, 口唇小唾液腺あるいは涙腺の生検組織における, 小葉内導管周囲の単核細胞の浸潤程度が, 最も重要な診断指標と考えられている. この診断基準では,「小唾液腺生検組織の小葉内導管周囲に50個以上の単核細胞の浸潤巣をfocusとみなし, 4mm2あたりのfocus数をfocus score(FS)とよび, FS1以上を陽性」としている.
Practice : 歯科学
Keywords : シェーグレン症候群, 口唇腺生検, 唾液腺シンチグラフィ

English

Title : A study for the relation of minor salivary gland biopsy and salivary gland function on patients with Sjogren's syndrome
Subtitle :
Authors : Takeo SHIMADA, Eiro KUBOTA, Takafumi ISHIDA, Shigeyuki OZAWA, Kenji SUZUKI, Masahiko DOHI, Hiroshi IWABUCHI, Yoshiro HONMA, Nobuhisa KUBOTA*
Authors(kana) :
Organization : Department of Oral and Maxillofacial Surgery, Kanagawa Dental University School of Dentistry, *Department of Diagnostic Pathology, Kanagawa Dental University Hospital
Journal : Kanagawa Shigaku
Volume : 49
Number : 1
Page : 34-40
Year/Month : 2014 / 6
Article : Original article
Publisher : Kanagawa Odontological Society
Abstract : [Abstract] To elucidate the relation of focus score (FS) in minor salivary gland biopsy and salivary gland function of Sjogren's syndrome (SS) patients, FS and salivary gland function detected by Tc-99m-pertechnetate scintigraphy (99mTc-scintigraphy) were compared. Twenty three patients with SS were divided into two groups according to FS. The one group consisted of SS patients with FS ranging from 1 to 2 (1<=FS<2), and the other consisted of SS patients with FS of 2 or more than 2 (2<=FS). The major salivary gland function was accessed by 99mTc-scintigraphy. Salivary gland function was evaluated by time activity curve (TAC) on the scintigraphy. We classified the TACs of parotid and submandibular glands into 4 types, normal (N) type, poor excretion (P) type, median (M) type, and flat (F) type. Any of P, M, and F types were considered as functionally deteriorated. Forty one point nine percent of salivary gland in eight patients with 1<=FS<2 exhibited dysfunction, whereas 68.7% of the salivary gland showed dysfunction in 8 patients with 2<=FS. These values were statistically significant. Furthermore, percentages of salivary dysfunction between parotid and submandibular glands in the same FS groups were statistically different. These results suggest that FS of the minor salivary gland biopsy may reflect the salivary dysfunction of the major salivary glands in SS. Furthermore, the submandibular gland is amenable to be affected in SS when compared with the parotid gland.
Practice : Dentistry
Keywords :