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アブストラクト（25巻1号：神奈川歯学）
Japanese
| Title ： | ラット顎下腺terminal tubule cellの細胞内自己貪食作用に関する研究 |
|---|---|
| Subtitle ： | 原著 |
| Authors ： | 伊藤由美*1,*2,*3, 久田太郎*2, 高橋和人*3 |
| Authors（kana） ： | |
| Organization ： | *1神奈川歯科大学病理学教室, *2神奈川歯科大学, *3神奈川歯科大学口腔解剖学教室 |
| Journal ： | 神奈川歯学 |
| Volume ： | 25 |
| Number ： | 1 |
| Page ： | 41-57 |
| Year/Month ： | 1990 / 6 |
| Article ： | 原著 |
| Publisher ： | 神奈川歯科大学学会 |
| Abstract ： | 「緒言」 ラット顎下腺の発生は胎生14～16日頃に口腔上皮の陥入と導管系の形成から始まり, 生後発達過程を経て成熟腺組織構造へと発展することが知られている. 生下時の腺終末部は, terminal tubule cell, proacinar cellおよびacinar cellの3種の細胞型で構成されたterminal tubuleよりなり, 未発達な導管系へ連絡している. terminal tubule cellとproacinar cellは生後発達過程で消退し, 腺終末部はacinar cellで成熟腺房を形成することが報告されている. proacinar cellは, Yamashinaらのendogenous peroxidase活性を指標とした検索によってacinar cellのprecursorであることが証明されており, その分化に伴って消退する. またterminal tubule cellについては, 離乳期を契機として細胞内空胞の形成を生じ, その後に細胞質の乏しい介在部導管細胞へtransformすることが示唆されている. |
| Practice ： | 歯科学 |
| Keywords ： | Terminal tubule cell, Autophagic vacuole, Unbuffered osmium method |
English
| Title ： | Studies on Cellular Autophagocytosis -Terminal Tubule Cells in Rat Submandibular Gland- |
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| Subtitle ： | |
| Authors ： | Yumi ITO*1,*2, Taro Hisada*1, Kazuto Takahashi*2 |
| Authors（kana） ： | |
| Organization ： | *1Department of Pathology, Kanagawa Dental College Kanagawa Dental College, *2Department of Oral Anatomy, Kanagawa Dental College |
| Journal ： | Kanagawa Shigaku |
| Volume ： | 25 |
| Number ： | 1 |
| Page ： | 41-57 |
| Year/Month ： | 1990 / 6 |
| Article ： | Original article |
| Publisher ： | Kanagawa Odontological Society |
| Abstract ： | [Abstract]: During the postnatal development of the rat submandibular gland, the origin of the membranes of the cytoplasmic vacuoles in terminal tubule cells was studied by light and electron microscopy. The terminal tubule cells before weaning contained the extensive endoplasmic reticulum, the small Golgi apparatus and abundant granules. Slight vacuolization was seen in the perinuclear area just before weaning, and after weaning the vacuoles rapidly increased in number. Acid phosphatase activity was localized in lysosomes and in newly formed vacuoles. The enzyme reaction product was also observed in the vesicles within the vacuoles. Using unbuffered osmium method, very intense staining was observed in the newly formed vacuoles as well as in the outer cisternae, the vesicles of Golgi apparatus and frequently in cavity between the double membranes of the endoplasmic reticulum. The newly formed vacuoles were a double membrane surrounding sacs which contained clearly recognizable cell organelles and/or secretory granules. Within the large vacuoles several organelles were present. Therefore, the cytoplasmic vacuoles in terminal tubule cells corresponded to crinophagy. These results suggest that the autophagic vacuoles in terminal tubule cells are derived from the endoplasmic reticulum and fused with lysosomes and then the inner membrane is gradually digested. |
| Practice ： | Dentistry |
| Keywords ： | Terminal tubule cell, Autophagic vacuole, Unbuffered osmium method |
