アブストラクト（30巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Oxidative Stress and Temporo-mandibular Dysfunction
Subtitle　： BKDC CLINICAL AND RESEARCH TOPICS : Research Topics from the KDC Research Center of Advanced Technology for Craniomandibular Function
Authors　： Eiro Kubota1, Masako Suga1, Satoshi Shimizu1, Hiroharu Kato1, Shigeyuki Ozawa1, Yoshiaki Kawai1, Hiroyuki Miyazaki2, Hirofumi Shoji2, Fumihiko Yoshino2, Masaichi-Chang-il Lee2
Authors（kana）　：
Organization　： 1Department of Oral and Maxillofacial Surgery, Kanagawa Dental College, 2Department of Pharmacology and the Electron Spin Resonance Center, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 30
Number　： 2
Page　： 141-145
Year/Month　： 2002 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： Recent studies have provided evidence that a variety of molecular species, including cytokines, matrix degrading enzymes, neuropeptides, and arachidonic acid catabolites may be involved in the progression of temporomandibular disorders (TMD). This paper describes the theory that mechanical stresses lead to accumulation of free radicals (oxidative stress) in affected articular tissues of the temporomandibular joint (TMJ). The authors postulate mechanisms that may be involved in the production of free radicals in the TMJ and in the subsequent induction of molecular events that may amplify damage to the articular tissues initiated by freee radicals. Such information should have broad appeal to the clinician involved in the management of TMD as well as to the basic scientist interested in bone, cartilage, and connective tissue pathology.
Practice　： Dentistry
Keywords　： Reactive oxygen species, Oxidative stress, Temporomandibular disorders, Temporomandibular joint