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アブストラクト（25巻2号：The Bulletin of Kanagawa Dental College）
English
| Title ： | Extracellular Matrix Proteins that Modulate Cell-Matrix Interactions in Bone |
|---|---|
| Subtitle ： | BKDC CLINICAL AND RESEARCH TOPICS : Adhesion Molecule |
| Authors ： | Takao Kubota, Yukimitsu Miyakawa, Sadao Sato |
| Authors（kana） ： | |
| Organization ： | Department of Orthodontics, Kanagawa Dental College |
| Journal ： | The Bulletin of Kanagawa Dental College |
| Volume ： | 25 |
| Number ： | 2 |
| Page ： | 125-129 |
| Year/Month ： | 1997 / 9 |
| Article ： | Report |
| Publisher ： | Kanagawa Odontological Society |
| Abstract ： | [Abstract] It has been reported that the extracellular matrix (ECM) mediates several fundamental cellular processes such as migration, proliferation and phenotypic expression. In bone tissues, these effects has been studied with the interaction of cell surface integrins and arginine-glycine-aspartate (RGD) sequence of ECM. There are several RGD containing proteins such as osteopontin and bone sialoprotein in bone. Both proteins mediate the osteoblast, osteocyte and osteoclast adhesion, but also regulate the mineralization. The other matrix proteins, however, interact different integrins by a non RGD-mediated mechanism such as osteonectin. These proteins have several modifications such as phosphorylation, sulfation and glycosylation, also degrade by enzymes. Therefore, some type of modification or fragmentation may affect the function of adhesive proteins. It suggests a key to understanding cellular functions. |
| Practice ： | Dentistry |
| Keywords ： | Bone, Integrin, Osteonectin (SPARC), Osteopontin, Bone sialoprotein (BSP) |
