アブストラクト（37巻2号：The Bulletin of Kanagawa Dental College）

The Bulletin of Kanagawa Dental College

English

Title　： Basic studies about development of metabolic syndrome diagnostic method to using saliva
Subtitle　： Selective Proceedings of 43rd General Meeting of Kanagawa Odontological Society, 2008
Authors　： Juri Saruta*1, Chikatoshi Sato*1, Kenichi Sasaguri*1, Sadao Sato*1, Naoto Shiiki*2, Yusuke Kondo*2, Keiichi Tsukinoki*2
Authors（kana）　：
Organization　： *1Department of Craniofacial Growth and Development, Division of Orthodontics, Kanagawa Dental College, *2Department of Diagnostic Science, Division of Pathology, Kanagawa Dental College
Journal　： The Bulletin of Kanagawa Dental College
Volume　： 37
Number　： 2
Page　： 141-143
Year/Month　： 2009 / 9
Article　： Report
Publisher　： Kanagawa Odontological Society
Abstract　： [ABSTRACT] Brain-derived neurotrophic factor (BDNF) promotes survival and differentiation of the cells of the central and peripheral nervous systems. BDNF has been identified in non-neural tissue, including the heart, lung, platelets, lymphocytes, and lacrimal glands. Although the role of BDNF in the adult CNS is unclear, there is a rapidly growing body of evidence implicating BDNF in neuronal degeneration/regeneration mechanisms. Previous studies have demonstrated that BDNF played a role in the eating behavior and glucose and lipid metabolism. In this study we measured the plasma BDNF and saliva BDNF levels in diagnosted high-fat diet group. Serum triacylglycerols, saliva triacylglycerols, serum leptine, total protein and total cholesterol of high-fat diet group was significantly higher than in control group. The plasma BDNF level was found to significantly increase in high-fat diet group in comparison to that in control group. These results provide the first evidence that an increased BDNF is associated with metabolic syndrome.
Practice　： Dentistry
Keywords　： BDNF, Metabolic Syndrome, Rat, Saliva